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When your life is sucky you get drunk and sleep with inappropriate men. It's your thing.
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At the end of the day faith is a funny thing. It turns up when you don't really expect it. It's like one day you realize that the fairy tale may be slightly different than you dreamed. The castle, well, it may not be a castle. And it's not so important happy ever after, just that its happy right now. See once in a while, once in a blue moon, people will surprise you, and once in a while people may even take your breath away.
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- Dr. George O'Malley: Do you remember when he wallpapered the hospital with pictures of you in your underwear?
- Dr. Isobel "Izzie" Stevens: Yeah. Yeah, I do.
- Dr. Alex Karev: It was before I knew you.
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- Dr. Meredith Grey: Did you let me scrub in for this operation because I slept with you?
- Dr. Derek Shepherd: Yes.
[Pause]
- Dr. Derek Shepherd: Just kidding.

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- Dr. Preston Burke: So, I have a question to ask. I checked the schedule and I noticed that both you and I are off tonight. I made reservations. I have a favorite restaurant.
- Dr. Cristina Yang: None of those were questions.

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- Dr. Alex Karev: Here's the thing - I like your rack.
- Dr. Isobel "Izzie" Stevens: God, what is wrong with you? Why do you have to be so - what is wrong with you?
- Dr. Alex Karev: I like your rack and I'd want them around if I could have them, trust me I would, but it wouldn't be the end of the world if you got rid of them... because really, I'd want *you*.
[Izzie slaps him]
- Dr. Alex Karev: Ow! What was that for?
[She kisses him]

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- Dr. Miranda Bailey: [To Cristina] An intern was reassigned so he's mine now. Have him shadow you for the day, show him how I do things.
- Dr. Alex Karev: Alex Karev, nice to meet you.
- Christina Yang: The pig who called Meredith a nurse. I hate you on principle.
- Dr. Alex Karev: And you're the pushy, overbearing kiss ass. I hate you too.
- Christina Yang: Oh, this should be fun then.

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[to a patient and rapist whose victim bit off his penis] I have good news and bad news. The good news is that we managed to stop the bleeding. The bad news is that we gave your penis to the cops.
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- Dr. Meredith Grey: After all this time, all your warnings about me sleeping with my boss and you're doing the same exact thing.
- Dr. Cristina Yang: Oh, it's not the same thing.
- Dr. Meredith Grey: It's the exact same!
- Dr. Cristina Yang: No, it's not. You and mcdreamy are in a relationship.
- Dr. Meredith Grey: And you and Burke are in?
- Dr. Cristina Yang: Switzerland. It's very neutral there and they make very nice watches.

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- Dr. Isobel "Izzie" Stevens: [Standing in the bathroom, outside the shower, where George is] I reminded you before you went.
- Dr. George O'Malley: I forgot when I got there.
- Dr. Isobel "Izzie" Stevens: No.
[She opens the shower door]
- Dr. Isobel "Izzie" Stevens: No, you were so passive aggressive!
- Dr. George O'Malley: Naked! I am naked in the shower!
- Dr. Isobel "Izzie" Stevens: [Closes the shower door] Just tampons, George! I really needed tampons. God!
[Meredith enters the bathroom]
- Dr. Isobel "Izzie" Stevens: I'm not riding in the same car as him.
- Dr. Meredith Grey: [Looks at Izzie, who is standing in her "Hello Kitty" underwear] Unless you're going like that, you're not riding with me either. Where are the tampons?
- Dr. Isobel "Izzie" Stevens: He didn't buy them.
- Dr. Meredith Grey: [To George] You didn't buy them?
- Dr. George O'Malley: Men don't buy tampons!
- Dr. Isobel "Izzie" Stevens: [Opens the shower door again, and George falls over] You know what? You're gonna have to get over the whole man thing, George! We're women! We have vaginas! Get used to it!
[She walks out of the bathroom, leaving George lying on the floor of the shower]
- Dr. George O'Malley: I am not your sister!
[He slams the shower door]