- Dr. Isobel "Izzie" Stevens: I'm a pretty girl.
- Dr. Richard Webber: What?
- Dr. Isobel "Izzie" Stevens: I'm not being arrogant, it's just... it's just kinda a fact. For a long time I made a career for my looks, so I get it. I'm a pretty girl. And not from a certain angle way, in an obvious way. It's the blonde thing, and the big boobs thing. Big boobs are key to obvious pretty, if you know what I'm saying.
- Dr. Richard Webber: Dr. Stevens...
- Dr. Isobel "Izzie" Stevens: That's how men see me. I'm not a smart girl or an interesting girl. I'm a pretty girl. The blonde and the boobs confuses guys into thinking that I'm someone else. And I'm used to it. I'm used to them walking away when they realize... but then Denny goes and asks me to marry him.
- Dr. Richard Webber: Is that why you cut the wires?
- Dr. Isobel "Izzie" Stevens: He doesn't make me feel like I'm a pretty girl. He makes me feel like... like me. I think he might know me. And so if I did cut the l-Vad wire, and I'm not saying I did, but if I did then no. I don't feel guilty. And I know that I should and I would if it were anybody else. But I can't feel anything but happy.