Quotes from the Movies featuring Patrick Dempsey

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- Dr. Derek Shepherd: Do you happen to know what time of year neurosurgeons are the busiest, Dr. Stevens?
- Dr. Isobel "Izzie" Stevens: There's a time of year?
- Dr. Derek Shepherd: There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Like our friend here. Folks fall off their roofs while they string up lights. Or they go skating for the first time in a decade and break their heads open. And every year people drive through blizzards to get to parties where they kiss germ-infected strangers under poisonous mistletoe. And then they get so drunk that they smash their heads through their windshield on their way home. Like I said, there's no hard or fast rule.

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Okay, here it is, your choice... it's simple, her or me, and I'm sure she is really great. But Derek, I love you, in a really, really big pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window, unfortunate way that makes me hate you, love you. So pick me, choose me, love me.

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- Dr. Meredith Grey: What was I to you? The girl you screwed to get over being screwed?
- Dr. Derek Shepherd: You were like coming up for fresh air. It's like I was drowning and you saved me. It's all I know.
- Dr. Meredith Grey: It's not good enough.