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Sometimes reality has a way of sneaking up and biting us in the ass. And when the dam bursts, all you can do is swim. The world of pretend is a cage, not a cocoon. We can only lie to ourselves for so long. We are tired, we are scared, denying it doesn't change the truth. Sooner or later we have to put aside our denial and face the world. Head on, guns blazing. De Nile. It's not just a river in Egypt, it's a freakin'ocean. So how do you keep from drowning in it?
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- Dr. Isobel "Izzie" Stevens: Mr. Humphrey? Mr. Humphrey, I'm sorry to wake you.
- Mr. Humphrey: C'mon. What time is it?
- Dr. Isobel "Izzie" Stevens: Ten after five. I'm sorry, I just need to do a brief exam. If you could just sit up for one moment.
[He sits up]
- Dr. Isobel "Izzie" Stevens: Thanks. This might be a little bit cold. So just take a deep breath.
[He looks at her funny]
- Dr. Isobel "Izzie" Stevens: If you could just take a deep breath.
- Mr. Humphrey: You're not a doctor!
- Dr. Isobel "Izzie" Stevens: I'm Dr. Stevens, but you can call me Izzie. I'll be helping Dr. Bailey with your biopsy this morning.
- Mr. Humphrey: No, I don't think so. No.
- Dr. Isobel "Izzie" Stevens: Mr. Humphrey, this will just take a moment.
- Mr. Humphrey: No, get me Dr. Bailey or Dr. Victor.
- Dr. Isobel "Izzie" Stevens: I - I just need to do a brief.
- Mr. Humphrey: You don't need to do anything. Is this you?
[He shows Izzie a picture in a magazine of herself posing in lingerie]
- Mr. Humphrey: Is this you? It is, isn't it? Get out of my room!
- Dr. Isobel "Izzie" Stevens: Mr. Humphrey.
- Mr. Humphrey: Get out of my room!

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What self-respecting surgeon wears salmon-colored scrubs?
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- Dr. Christina Yang: [They all see the Nazi] That's the Nazi?
- Dr. George o'Malley: I thought the Nazi would be a man.
- Dr. Meredith Grey: I thought the Nazi would be... the Nazi.
- Dr. Isobel "Izzie" Stevens: [Izzie walks up behind them] Maybe it's professional jealousy. Maybe she's brilliant and they call her a Nazi because they're jealous. Maybe she's nice.
- Dr. Christina Yang: Let me guess - you're the model.
- Izzie gives her an evil look.
- Dr. Isobel "Izzie" Stevens: [to the Nazi] Hi, I'm Isobel Stevens, but everyone just calls me Izzie.
- Dr. Miranda Bailey: I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.

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- Dr. Derek Shepherd: Do you happen to know what time of year neurosurgeons are the busiest, Dr. Stevens?
- Dr. Isobel "Izzie" Stevens: There's a time of year?
- Dr. Derek Shepherd: There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Like our friend here. Folks fall off their roofs while they string up lights. Or they go skating for the first time in a decade and break their heads open. And every year people drive through blizzards to get to parties where they kiss germ-infected strangers under poisonous mistletoe. And then they get so drunk that they smash their heads through their windshield on their way home. Like I said, there's no hard or fast rule.

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- Dr. Meredith Grey: I think she's more of a "gentle stalker.
- Dr. Miranda Bailey: Right. Well, let's hope she lives to "gently stalk" another day.

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Christmas makes you want to be with people you love. I'm not saying this to hurt you, or because I want to leave you, because I don't. Meredith wasn't a fling. She wasn't revenge. I fell in love with her. That doesn't go away because I decided to stay with you.
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I gotta go. You stay here. You are a gifted surgeon with an extraordinary mind. Don't let what he wants eclipse what you need. He's very dreamy, but he's not the sun. You are.
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I want facts and until I get them my pants are staying on.
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- Dr. Meredith Grey: Goodbye, Derek.
- Dr. Derek Shepherd: Goodbye, Meredith.